purine analog definition - Symptoms of Gout and its Causes
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Symptoms of Gout and its Causes

Gout is also known as crystal-induced arthritis. It is a medical condition that sets in when uric acid crystals collect on the joints. At the first stage, gout usually affects the large joints in the big toe. Gradually it can spread to other parts of the body, like the ankles, the instep, the heels and the knees, the wrists and fingers of the hand and the elbows. In severe cases, even the shoulders, hips or spine can be affected. Gout does not spread from one joint to the next. Uric acid is a metabolic end product that is formed at the time the body breaks down purines present in certain food items. In normal conditions, the uric acid gets dissolved in the blood and gets eliminated from the body through the kidneys into the urine. However, people having a propensity for gout have such high levels of uric acid in their blood that the acid precipitates out in the form of crystals. The crystals get accumulated on the joints and other tissues, leading to inflammation and excruciating pain. A chronic condition can lead to the formation of tophi lumps formed under the skin due to large deposits on severely affected joints of the elbow, fingers and toes, and even on the external pinna.


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  Another medical condition, referred to as the pseudo-gout, results from the deposits of calcium-based crystals in the joints.

In almost 90 percent of incidences of gout, men over the age of 40 and menopausal women are affected. An "episode" often takes place during the night. Within 12 to 24 hours of the onset, the afflicted joint becomes severely inflamed and starts to ache rigorously. The gout attack usually lasts about five to 10 days.

The Signs and Symptoms of Gout include:

Hyperuricemia

Presence of uric acid crystals in joint fluid

More than one attack of acute arthritis

Arthritis that develops in 1 day

Attack of arthritis in only one joint, usually the toe, ankle, or knee

A painful joint that is swollen, red, and warm

The probable causes of gout include:

 
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Genetic defects in metabolism resulting in hyper-production and retention of uric acid in the blood

Kidney failure leading to hampered elimination of uric acid from the body

Diuretic medications employed in the treatment of heart failure and diabetes.

Erratic lifestyle, alcohol abuse, purine-rich diet and excess weight

Surgery or sudden injury, severe illness

Proper understanding of the cause and symptoms of gout can help in achieving a successful cure for gout attacks. Want to learn more about Gout Symptom Sign?, feel free to visit us at: http://www.about-goat.info/Articles/Gout_Symptoms.php

 
 
     
 
 





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What is gout? Gout is a type of arthritis. It is caused by the buildup of uric acid in your joints. It can affect the foot, heel, ankle, elbow, wrist or hand. Most often though, it affects the big toe. Gout is a reoccurring problem that comes and goes. It usually comes on without warning, and then goes away after 7-10 days. What causes gout? Uric...


Sometimes, even if a person lives a healthy lifestyle, abstains from alcohol or drinks it modestly, they can experience a condition that mirrors gout, but is in actuality, a different arthritic condition altogether known as pseudogout. To help you understand the differences between these two, the following is a breakdown of the causes, symptoms and treatments for each condition. Gout Gout...


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Turf toe gets no respect. Let's take a closer look at the causes of turf toe and see how to treat it more effectively. Turf toe is actually a form of hallux limitus. Hallux limitus is classically described as pain and progressive decrease in the range of motion of the first metatarsal phalangeal joint (MPJ). The onset of hallux limitus is due to the following: Functional hallux limitus -...


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purine analog definition | Symptoms of Gout and its Causes
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purine analog definition | Symptoms of Gout and its Causes
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